1996 Research Publications

Pathology

Books and Chapters

Heenan, P.J., Elder, D.E. and Sobin, L.H. Histological Typing of Skin Tumours, Germany, Springer-Verlag (1996)

Kakulas, B.A. The Spectrum of Dystrophinopathies, Handbook of Muscle Disease, ed R.J.M. Lane, New York NY, Marcel Dekker, Inc., 1: pp 235-244 (1996)

Mastaglia, F.L. and Kakulas, B.A. X-Linked Dystrophies: Clinical and Pathological Features, Handbook of Muscle Disease, ed R.J.M. Lane, New York NY, Marcel Dekker, Inc., 1: pp 201-221 (1996)

Price, P. and Papadimitriou, J.M. Genetic and Immunologic Determinants of Age-Related and Virus-Induced Cardiopathy, Pathobiology of the Aging Mouse, eds U. Mohr, D.L. Dungworth, C.C. Capen, W.W. Carlton, J.P. Sundberg, J.M. Ward, Washington, DC, USA, International Life Sciences Institute Press, 1: pp 373-383 (1996)

Journal Articles

Andoniou, C.E., Thien, C.B.F. and Langdon, W.Y. The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain, Oncogene, 12: pp 1981-1989 (1996)

Ashman, R.B., Papadimitriou, J.M. and Fulurija, A. Acute labyrinthitis associated with systemic Candida albicans infection in ageing mice, The Journal of Laryngology and Otology, 110:January, pp 13-18 (1996)

Ashman, R.B., Fulurija, A. and Papadimitriou, J.M. Strain-Dependent Differences in Host Response to Candida albicans Infection in Mice Are Related to Organ Susceptibility and Infectious Load, Infection and Immunity, 64:5, pp 1866-1869 (1996)

Ashman, R.B. Cytokine in Candida albicans infection. Current views and new perspectives, Revista Iberoamericana de Micologia, 13: pp 85-86 (1996)

Bartlett, R.J., Howell, J.M., Cooper, B.J., Kornegay, J.N., Winand, N.J., Secore, S.L., Singer, J.T., Fletcher, S., Wilton, S., Bogan, D.J., Metcalf-Bogan, J.R. and Bartlett, W.T. Mutation segregation and rapid carrier detection of X-linked muscular dystrophy in dogs, American Journal of Veterinary Research, 57:5, pp 650-654 (1996)

Caterina, P., Warton, A., Papadimitriou, J.M. and Ashman, R.B.Relationship of the virulence of Trichomonas vaginalis and the major histocompatibility complex in murine trichomonad infection, Parasitology Research, 82: pp 628-633 (1996)

Choong, P.L., deSilva, C.J.S., Dawkins, H.J.S., Sterrett, G.F., Robbins, P., Harvey, J.M., Papadimitriou, J. and Attikiouzel, Y. Predicting axillary lymph node metastases in breast carcinoma patients, Breast Cancer Research and Treatment, 37: pp 135-149 (1996)

Daly, S.E.J., Kent, J.C., Owens, R.A. and Hartmann, P.E. Frequency and degree of milk removal and the short-term control of human milk synthesis, Experimental Physiology, 81: pp 861-875 (1996)

Donovan, J.A., Ota, Y., Langdon, W.Y. and Samelson, L.E. Regulation of the Association of p120cbl with Grb2 in Jurkat T Cells, The Journal of Biological Chemistry, 271:42 October 18, pp 26369-26374 (1996)

Dunne, J.W., Heye, N., Edis, R.H. and Kakulas, B.A. Necrotizing inflammatory myopathy associated with localized scleroderma, Muscle & Nerve, 19:August, pp 1040-1042 (1996)

Fabian, V.A., Jones, T.M., Wilton, S.D., Dench, J.E., Davis, M.R., Lim, L. and Kakulas, B.A. Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series, Medical Journal of Australia, 165:15 July, pp 77-80 (1996)

Fan, Y., Beilharz, M.W. and Grounds, M.D. A potential alternative strategy for myoblast transfer therapy: the use of sliced muscle grafts, Cell Transplantation, 5:3, pp 421-429 (1996)

Fan, Y., Maley, M., Beilharz, M. and Grounds, M. Rapid death of injected myoblasts in myoblast transfer therapy, Muscle & Nerve, 19: pp 853-860 (1996)

Forbes, G.M., Horne, R., Erber, W.N., Collins, B.J. and Papadimitriou, J.M.Ultrastructural evidence of intestinal mucosal macrophage activation after bone marrow transplantation, Pathology, 28: pp 251-254 (1996)

Frayne, J., Sterrett, G.F., Harvey, J., Goodwin, P., Townsend, J., Ingram, D. and Parsons, R.W. Stereotactic 14 gauge core-biopsy of the breast: results from 101 patients, Australian and New Zealand Journal of Surgery, 66: pp 585-591 (1996)

Fulurija, A., Ashman, R.B. and Papadimitriou, J.M. Early inflammatory responses to Candida albicans infection in inbred and complement-deficient mice, FEMS Immunology and Medical Microbiology, 14: pp 83-94 (1996)

Fulurija, A., Ashman, R.B. and Papadimitriou, J.M. Neutrophil depletion increases susceptibility to systemic and vaginal candidiasis in mice, and reveals differences between brain and kidney in mechanisms of host resistance, Microbiology, 142: pp 3487-3496 (1996)

Hahnel, R. and Hahnel, E. Expression of the PIP/GCDFP-15 gene and survival in breast cancer, Virchows Archiv - An International Journal of Pathology, 429: pp 365-369 (1996)

Hahnel, R., Harvey, J. and Kay, P. Hypermethylation of the Myogenic Gene Myf-3 in Human Breast Carcinomas, Anticancer Research, 16: pp 2111-2116 (1996)

Harmon, D. and Kay, P.H. Polymorphism of Pax7 in the wild mouse gene pool, Mouse Genome, 94:4, December, pp 868-870 (1996)

Hilliard, C.M., Fletcher, S. and Yeoh, G.C.T. Calcium Phosphate Transfection and Cell-Specific Expression of Heterologous Genes in Primary Fetal Rat Hepatocytes, International Journal of Biochemistry and Cell Biology, 28:6, pp 639-650 (1996)

Hong, Y., Chirila, T.V., Vijayasekaran, S., Davies, M.J. and Maley, M.A.L. In Vitro Cytotoxicity Assay of Synthetic Hydrogels as Potential Vitreous Substitutes, In Vitro Toxicology, 9:1, pp 73-82 (1996)

Hosler, B.A., Yeung, L., Cherryson, A.K., Dench, J.E., Wilton, S.D., Laing, N.G., Horvitz, H.R., Brown, R.H., Nicholson, G.A., Sapp, P.C., Chin, W., Orrell, R.W., De Belleroche, J.S., Esteban, J., Hayward, L.J. and McKenna-Yasek, D.Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis, Neuromuscular Disorders, 6:5, pp 361-366 (1996)

Kakulas, B.A. Neuromuscular diseases: muscle, Current Opinion in Neurology, 9: pp 367-368 (1996)

Kakulas, B.A., Wilton, S.D., Fabian, V.A. and Jones, T.M. Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease, The Lancet, 348:August 17, p 483 (1996)

Lupher, M.L.JR., Reedquist, K.A., Miyake, S., Langdon, W.Y. and Band, H. A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells, The Journal of Biological Chemistry, 271:39, September 27, pp 24063-24068 (1996)

Marlow, S.A., Kay, P.H. and Papadimitriou, J.M. Polymorphism of the mouse E2A gene due to an intronic deletion of 536 bp, Gene, 168: pp 143-149 (1996)

Marlow, S.A., McGeachie, J.K., Tennant, M. and Papadimitriou, J.M. A morphometric technique for the histological quantification of skeletal muscle regeneration, Journal of Anatomy, 189: pp 151-158 (1996)

Mitchell, C.A., Davies, M.J., Grounds, M.D., McGeachie, J.K., Crawford, G.J., Hong, Y. and Chirila, T.V. Enhancement of Neovascularization in Regenerating Skeletal Muscle by the Sustained Release of Erucamide from a Polymer Matrix, Journal of Biomaterials Applications, 10:January, pp 230-249 (1996)

Mutsaers, S.E., Whitaker, D. and Papadimitriou, J.M. Changes in the concentration of microvilli on the free surface of healing mesothelium are associated with alterations in surface membrane charge, Journal of Pathology, 180: pp 333-339 (1996)

Papadopulos-Eleopulos, E., Turner, V.F., Causer, D.S. and Papadimitriou, J.M. HIV transmission by donor semen, The Lancet, 347:January 20, pp 190-191 (1996)

Rakoczy, P.E., Lai, M.C., Viyayasekaran, S., Robertson, T., Rapp, L., Papadimitriou, J. and Constable, I. Initiation of impaired outer segment degradation in vivo using an antisense oligonucleotide, Current Eye Research, 15: pp 119-123 (1996)

Randall, A.G., Will, R.K., Retallack, R.W., Price, R.I., Ward, L., Kent, G.N., Garcia-Webb, P., Bhagat, C.I., Pearce, D.J., Gutteridge, D.H., Prince, R.L., Stewart, G. and Stuckey, B. Comparison of Biochemical Markers of Bone Turnover in Paget Disease Treated with Pamidronate and a Proposed Model for the Relationships Between Measurements of the Different Forms of Pyridinoline Cross-links, Journal of Bone and Mineral Research, 11:8, pp 1176-1184 (1996)

Reedquist, K.A., Fukazawa, T., Panchamoorthy, G., Langdon, W.Y., Shoelson, S.E., Druker, B.J. and Band, H. Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G, The Journal of Biological Chemistry, 271:14, April 5, pp 8435-8442 (1996)

Stanton, J.L., Wilton, S.D. and Laing, N.G. Characterisation of the chicken Cu,Zn superoxide dismutase gene, DNA Sequence, 6: pp 357-360 (1996)

Sterrett, G.F., Harvey, J., Robbins, P. and de Klerk, N. To the Editor in reply to a letter on the journal article "Histological Grading of Breast Carcinomas: A Study of Interobserver Agreement" published by the above authors in a copy of the journal published in 1995, Human Pathology, 27:6, June, p 618 (1996)

Townsend, K.M., Dawkins, H.J.S., Zeng, B.J., Watson, M.W. and Papadimitriou, J.M.Cloning of a unique sequence specific to isolates of type B:2 Pasteurella multocida, Research in Veterinary Science, 61: pp 199-205 (1996)

Tuffin, M.J., Rakoczy, P.E., Lai, M.C., Papadimitriou, J.M. and Constable, I.J.Cloning of VEGF165 into expression vector for protein production, Australian and New Zealand Journal of Ophthalmology, 24 Supplement:2, pp 81-84 (1996)

Wang, L.T., Smith, A., Iacopetta, B., Wood, D.J., Papadimitriou, J.M. and Zheng, M.H. Nested PCR-SSCP assay for the detection of p53 mutations in paraffin wax embedded bone tumours: improvement of sensitivity and fidelity, Clinical Molecular Pathology, 49:3, pp M176-M178 (1996)

Wang, Y., Yeung, Y-G., Langdon, W.Y. and Stanley, E.R. c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages, The Journal of Biological Chemistry, 271:1, pp 17-20 (1996)

Wilton, S. and Lim, L. Long-range PCR: synthesis of products independent of size, Trends in Genetics, 12: p 458 (1996)

Wilton, S.D., Lim, L., Dorosz, S.D., Gunn, H.C., Eyre, H.J., Callen, D.F. and Laing, N.G. Assignment of the human a-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization, Cytogenetics and Cell Genetics, 72: pp 294-296 (1996)

Wysocki, S.J., Zheng, M.H., Smith, A., Lamawansa, M.D., Iacopetta, B.J., Robertson, T.A., Papadimitriou, J.M., House, A.K. and Norman, P.E.Monocyte Chemoattractant Protein-1 Gene Expression in Injured Pig Artery Coincides With Early Appearance of Infiltrating Monocyte/Macrophages, Journal of Cellular Biochemistry, 62: pp 303-313 (1996)

Zeps, N., Dawkins, H.J.S., Papadimitriou, J.M., Redmond, S.L. and Walters, M.N-I. Detection of a population of long-lived cells in mammary epithelium of the mouse, Cell and Tissue Research, 286: pp 525-536 (1996)

Conference Publications

Hahnel, R. Fatty Acid Synthetase (FAS) and Survival in Breast Cancer, 7th EORTC Breast Cancer Working Conference, Oxford England, Elsevier Science Ltd, 32A Supplement 2: p 56 (1996)

Howell, J.MCC., Fletcher, S., Kakulas, B.A. and Barnes, A. Gene therapy in the dog model for Duchenne muscular dystrophy, Vth European Congress of Neuropathology, Oxford, Blackwell Science Ltd, 22, Supplement 1, May: p 3 (1996)

Jacobsen, P.F., Daly, J., Butler, T. and Fabian, V. Induction of neoplasia in normal murine host cells by xenografted glioblastoma multiforme, Vth European Congress of Neuropathology, Oxford, Blackwell Science Ltd, 22, Supplement 1, May: p 59 (1996)

Kakulas, B.A. The early white matter lesions in human spinal cord injury, Vth European Congress of Neuropathology, Oxford, Blackwell Science Ltd, 22, Supplement 1, May: p 16 (1996)

Kakulas, B.A., Harker, N.A., Laing, N.G., Johnsen, R.D. and Silberstein, E.P.Molecular diagnosis of childhood myopathies, First Congress of the World Muscle Society, Oxford, Elsevier Science Ltd, Supplement, September 1996: p S58 (1996)

Tan, P., Wilton, S.D., Akkari, P.A., Sharp, M., Allen, J., Huxtable, C. and Laing, N.G. A splice-site mutation causes ovine McArdle's disease, First Congress of the World Muscle Society, Oxford, Elsevier Science Ltd, Supplement, September 1996: p S62 (1996)

Wallgren-Pettersson, C. and Laing, N.G. Nemaline Myopathy, 40th European Neuromuscular Centre (ENMC) sponsored international workshop, Great Britain, Elsevier Science Ltd, 6: pp 389-391 (1996)

Wallgren-Pettersson, C., Ridanpaa, M., Donner, K., Pelin, K., Laing, N. and de la Chapelle, A. Relocalisation of the nebulin gene to a more proximal region on chromosome 2q using radiation hybrids, First Congress of the World Muscle Society, Oxford, Elsevier Science Ltd, Supplement, September 1996: pp S58-S59 (1996)

Winship, I., Dench, J.E., Harker, N.A. and Laing, N.G. Spinal muscular atrophy following sperm donated pregnancy, First Congress of the World Muscle Society, Oxford, Elsevier Science Ltd, Supplement, September 1996: p S32 (1996)

Yu, L.L., Heenan, P.J. and Eldon, M.J. p53 expression in desmoplastic melanoma, 21st Annual Scientific Meeting of the Australasian Division of the International Academy of Pathology and the 1st Conjoi, New York NY USA, Churchill Livingstone International, 3: p 208 (1996)

Others

Andoniou, C.E., Thien, C.B.F. and Langdon, W.Y. Identification of two major cbl phosphorylation sites in abl-transformed cells, 8th Lorne Cancer Conference. Proceedings. Erskine House, Lorne. February 8-11 1996, Melbourne (1996)

Bolitho, E.M., Grounds, M.D. and Beilharz, M.W. Expression of myogenic regulatory genes following injury to skeletal muscles of BALB/c and SJL/J mice, Australia and New Zealand Society for Cell Biology, Inc. 15th Annual Meeting. Differentiation, Development and Disease, Brisbane (1996)

Edel, M.J., Dawkins, H.J.S., Robbins, P.D., Papadimitriou, J.M., Harvey, J.M. and Mitchell, C.A. Association of Vascularity and Axillary Lymph Node Metastasis of Breast Carcinoma, 7th Annual Combined Biological Sciences Meeting Perth, 1996, Perth (1996)

Fuji, H., Seydel, U., Papadimitriou, J.M., Wood, D.J. and Zheng, M.H. Reduction of osteoclast mitochondrial transmembrane potential with increasing multinucleation, Australian and New Zealand Bone & Mineral Society. Annual Scientific Meeting. Sydney, Australia. Volume 6. October 1, Sydney (1996)

Fulurija, A., Ashman, R.B. and Papadimitriou, J.M. Neutrophil depletion increases susceptibility to systemic and vaginal candidiasis in mice, and reveals differences between brain and kidney in mechanisms of host resistance, Interaction - Development - Growth. FIMSA The Federation of Immunological Societies of Asia-Oceania. First Congress., Adelaide (1996)

Howell, J.MCC., Fletcher, S., Kakulas, B.A., O'Hara, M. and Karpati, G. Use of the dog model for Duchenne muscular dystrophy in gene therapy trials, Gene Therapy Workshop. 30-31 May 1996. Australian Neuromuscular Research Institute, Perth, Western Australia, Perth (1996)

Kakulas, B.A. (Review)The differential diagnosis of the human dystrophinopathies and related disorders, 9: pp 380-388, Philadelphia PA USA (1996)

Kakulas, B.A. Potential for gene therapy in Duchenne muscular dystrophy, Gene Therapy Workshop. 30-31 May 1996. Australian Neuromuscular Research Institute. Perth, Western Australia, Perth (1996)

Kakulas, B.A., Stepien, E.F., Gubbay, A.D., Lorimer, R.L. and Tizard, B.K. The clinical neuropathology of human spinal cord injury with reference to early changes, Australian Spinal Research Trust. "Frontiers of spinal cord research" at The Walter and Eliza Hall Institute of Medical, Melbourne (1996)

Kakulas, B.A., Harker, N.A., Laing, N.G., Johnsen, R.D. and Silberstein, E.P. Molecular diagnosis of inherited myopathies, 9th Asian Oceanian Congress of Neurology Abstract, Seoul Korea (1996)

Lai, N., Harker, N.A., Dasig, D., Fabian, V.A. and Kakulas, B.A. A limb girdle syndrome with unique features, 1996 Annual scientific meeting of the Australian Association of Neurologists & satellite meeting of the Movement Disorde, Perth (1996)

Laing, N.G., Tan, P., Wilton, S.D., Akkari, P.A., Johnsen, R.D., Sharp, M., Allen, J. and Huxtable, C. Ovine models of McArdle's disease and muscular dystrophy, Gene Therapy Workshop. 30-31 May 1996. Australian Neuromuscular Research Institute. Perth, Western Australia, Perth (1996)

Langdon, W.Y., Andoniou, C.E. and Thien, C.B.F. Interactions between cbl and the EGF receptor, 5th Hanson Symposium. Molecular Mechanisms of Oncogenesis. November 4 to 7 1996, Royal Adelaide Hospital, Adelaide, Au, Adelaide(1996)

Langdon, W.Y., Andoniou, C.E., Thien, C.B.F. and Bowtell, D.D.L. The involvement of cbl with the abl and EGF receptor protein tyrosine kinases, 8th Lorne Cancer Conference. Proceedings. Erskine House, Lorne. February 8-11 1996, Melbourne (1996)

Langdon, W.Y., Andoniou, C.E. and Thien, C.B.F. The involvement of cbl with the EGF receptor, Abstracts of papers presented at the Twelfth Annual Meeting on Oncogenes. June 18-22 1996. Hood College, Frederick, Ma, Maryland (1996)

Lau, T.T.A., Panicker, A.K., Wood, D.J., Papadimitriou, J.M. and Zheng, M.H. Recombinant human IL-1B IL-6 and IL-11 enhance the accumulation of 1,25 dihydroxyvitamin D3-induced carbonic anhydrase 11 gene transcripts in UL-60 cells, Australian and New Zealand Bone & Mineral Society. Annual Scientific Meeting. Sydney, Australia. Volume 6. October 1, Sydney (1996)

Mann, C.J., Fletcher, S., Wilton, S.D.and Howell, J.MCC. Use of the GRMD model to study gene and genetic therapies for muscular dystrophy, 7th Annual Combined Biological Sciences Meeting Perth, 1996, Perth (1996)

Mastaglia, F.L. and Laing, N.G. (Review)Investigation of muscle disease, 60: pp 256-274, London England (1996)

Mok, D. and Hahnel, R. Retinoic acid receptors in breast cancer biopsies, 8th Lorne Cancer Conference. Proceedings. Erskine House, Lorne. February 8-11 1996, Melbourne (1996)

Papadopulos-Eleopulos, E., Turner, V.F., Papadimitriou, J.M., Causer, D., Hedland-Thomas, B. and Page, B.A.P. Chapter: A critical analysis of the HIV-T4-cell-AIDS hypothesis, Book: AIDS: Virus - or Drug Induced?, 5:3-22, The Netherlands by Kluwer Academic Publi (1996)

Papadopulos-Eleopulos, E., Turner, V.F., Papadimitriou, J.M. and Causer, D. Chapter: Factor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationship, Book: AIDS: Virus - or Drug Induced?, 5:23-48, The Netherlands by Kluwer Academic Publi (1996)

Pearce, D.J., Kent, G.N., Randall, A.R. and Will, R.K. Collagen crosslink variation in osteoporotic and osteoarthritic articular cartilage, Australian and New Zealand Bone & Mineral Society. Annual Scientific Meeting. Sydney, Australia. Volume 6. October 1, Sydney (1996)

Robertson, H., Langdon, W., Thien, C. and Bowtell, D.D.L. Biochemical and Genetic analysis of the c-cbl proto-oncogene, 8th Lorne Cancer Conference. Proceedings. Erskine House, Lorne. February 8-11 1996, Melbourne (1996)

Silvia, O.J., Mansfield, J.P., Lancaster, M.U., Shellam, G.R., Papadimitriou, J.M. and Urosevic, N. In situ hybridisation of MurrayValleyencephalitis virus RNA in the brains of flavivirus susceptible and resistant mice, 7th Annual Combined Biological Sciences Meeting Perth, 1996, Perth(1996)

Silvia, O.J., Papadimitriou, J., Shellam, G.R., Allan, J.E. and Urosevic, N.U. The effect of flavivirus infection on the accummulation of CD 4+ and CD 8+ T cells in the brains of susceptible and resistant mice, Interaction - Development - Growth. FIMSA The Federation of Immunological Societies of Asia-Oceania. First Congress., Adelaide (1996)

Sparrow, L.E., Hollams, E., Dawkins, H.J.S. and Heenan, P.J. Analysis of EGFR in melanoma cell lines and melanocytic tumours, 8th Lorne Cancer Conference. Proceedings. Erskine House, Lorne. February 8-11 1996, Melbourne (1996)

Tan, P., Briner, J., Boltshauser, E., Davis, M.R., Wilton, S.D., Wallgren-Pettersson, C. and Laing, N.G. Homozygosity for a nonsense mutation in the alpha-tropomyosin gene TPM3 in a patient with fatal, congenital, nemaline myopathy with intranuclear rods, 7th Annual Combined Biological Sciences Meeting Perth, 1996, Perth (1996)

Thien, C.B.F., Andoniou, C.E. and Langdon, W.Y. A loss-of-function mutation from the C. elegans sli-1 gene in v-cbl ablates transformation and abolishes binding to the EGF receptor, 8th Lorne Cancer Conference. Proceedings. Erskine House, Lorne. February 8-11 1996, Melbourne (1996)

Thien, C.B.F. and Langdon, W.Y. Direct EGF receptor binding and transformation by the v-cbl oncoprotein is abolished by a loss-of-function mutation from the C.elegans cbl homologue SLI-1, 5th Hanson Symposium. Molecular Mechanisms of Oncogenesis. November 4 to 7 1996, Royal Adelaide Hospital, Adelaide, Au, Adelaide (1996)

Wilton, S., Dye, D., Blechynden, L. and Laing, N. Revertant Fibres: A possible genetic therapy for Duchenne muscular dystrophy, Gene Therapy Workshop. 30-31 May 1996. Australian Neuromuscular Research Institute. Perth, Western Australia, Perth (1996)

Wilton, S., Dye, D., Blechynden, L. and Laing, N. Revertant fibres: a possible genetic therapy for DMD, Cambridge Symposia. Molecular Genetic Approaches to the Treatment of Genetic Disease. Abstract Volume 4, 1996. Octobe, 4:, Nevada, USA (1996)